文章基本信息

标题：Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS
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作者：Almut Scherer ; John Frater ; Annette Oxenius 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：33
页码：12266-12270
DOI：10.1073/pnas.0404091101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：There are significant associations between possession of certain HLA class I alleles and rate of progression to AIDS. Immunological data provide an explanatory mechanism for this relationship. Patients with HLA types associated with rapid disease progression recognize a significantly smaller fraction of their known repertoire of viral epitopes than do patients with HLA types associated with slow progression. Population frequency of HLA types (or supertypes) and their capacity to elicit cytotoxic T lymphocyte responses are also negatively correlated. These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV.