文章基本信息

标题：The total synthesis of (–)-crispatene
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作者：Aubry K. Miller ; Daniel H. Byun ; Christopher M. Beaudry 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：33
页码：12019-12023
DOI：10.1073/pnas.0401787101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The total synthesis of the molluscan polypropionate (-)-crispatene is described. The synthesis features a palladium-catalyzed cross-coupling to establish a sensitive conjugated tetraene and its Lewis acid-catalyzed cycloisomerization to yield the bicyclo[3.1.0]hexene core of the natural product. The absolute configuration of (-)-crispatene and related molecules is established.