文章基本信息

标题：β-Adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses
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作者：B. A. Strange ; R. J. Dolan
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：31
页码：11454-11458
DOI：10.1073/pnas.0404282101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Human emotional experience is typically associated with enhanced episodic memory. We have used functional magnetic resonance imaging to demonstrate that successful encoding of emotional, compared to neutral, verbal stimuli evokes increased human amygdala responses. Items that evoke amygdala activation at encoding evoke greater hippocampal responses at retrieval compared to neutral items. Administration of the {beta}-adrenergic antagonist propranolol at encoding abolishes the enhanced amygdala encoding and hippocampal retrieval effects, despite propranolol being no longer present at retrieval. Thus, memory-related amygdala responses at encoding and hippocampal responses at recognition for emotional items depend on {beta}-adrenergic engagement at encoding. Our results suggest that human emotional memory is associated with a {beta}-adrenergic-dependent modulation of amygdala-hippocampal interactions.