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  • 标题:Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles
  • 本地全文:下载
  • 作者:Hiroki R. Ueda ; Wenbin Chen ; Yoichi Minami
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2004
  • 卷号:101
  • 期号:31
  • 页码:11227-11232
  • DOI:10.1073/pnas.0401882101
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Detection of individual body time (BT) via a single-time-point assay has been a longstanding unfulfilled dream in medicine, because BT information can be exploited to maximize potency and minimize toxicity during drug administration and thus will enable highly optimized medication. To achieve this dream, we created a "molecular timetable" composed of >100 "time-indicating genes," whose gene expression levels can represent internal BT. Here we describe a robust method called the "molecular-timetable method" for BT detection from a single-time-point expression profile. The power of this method is demonstrated by the sensitive and accurate detection of BT and the sensitive diagnosis of rhythm disorders. These results demonstrate the feasibility of BT detection based on single-time-point sampling, suggest the potential for expression-based diagnosis of rhythm disorders, and may translate functional genomics into chronotherapy and personalized medicine.
  • 关键词:DNA microarray ; gene expression ; chronotherapy
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