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标题：Trim5α protein restricts both HIV-1 and murine leukemia virus
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作者：Melvyn W. Yap ; Sébastien Nisole ; Clare Lynch 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：29
页码：10786-10791
DOI：10.1073/pnas.0402876101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Replication of HIV-1 and N-tropic murine leukemia virus (N-MLV) is restricted in a number of different primate cells. In some cell lines, cross-saturation experiments suggest that the two viruses are interacting with the same restriction factor. Recently, Trim5{alpha} protein from rhesus monkey was found to restrict HIV-1. We have confirmed this result and have shown that Trim5{alpha} from two African green monkey cell lines, Vero and CV-1, also restricts HIV-1. In addition, we show that human, rhesus, and African green monkey Trim5{alpha} can restrict N-MLV. By using a panel of MLV capsid mutants, subtle differences in the anti-MLV activity were identified among the different primate Trim5{alpha} cDNAs. Trim1 isolated from humans and green monkeys was also found to restrict N-MLV. We hypothesize that the Trim family of proteins plays a widespread role in innate immunity to viral infection.