文章基本信息

标题：Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells
本地全文：下载
作者：Yanan Zhu ; Bradley J. Swanson ; Michael Wang 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：20
页码：7681-7686
DOI：10.1073/pnas.0402293101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Apoptosis in activated T cells in vivo requires the proapoptotic Bcl-2 family member Bim. We show here that, despite its ability to bind LC8, a component of the microtubule dynein motor complex, most of the Bim in both healthy and apoptotic T cells is associated with mitochondria, not microtubules. In healthy resting T cells Bim is bound to the antiapoptotic proteins Bcl-2 and Bcl-xL. In activated T cells, levels of Bcl-2 fall, and Bim is associated more with Bcl-xL and less with Bcl-2. Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 family members on mitochondria rather than by sequestration to the microtubules.