文章基本信息

标题：Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines
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作者：Chunmei Wei ; Joel T. Mague ; Chao-Jun Li 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：16
页码：5749-5754
DOI：10.1073/pnas.0307150101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A Cu(I)-catalyzed direct addition of alkynes to imines was developed. The process is simple and provides a diverse range of propargylamines in high enantiomeric excess and good yield both in water and in toluene. The absolute configuration of such addition products has been determined by x-ray crystallography.