文章基本信息

标题：Highly enantioselective alkyne additions to aldehydes in the presence of 1,1′-bi-2-naphthol and hexamethylphosphoramide
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作者：Ge Gao ; Ru-Gang Xie ; Lin Pu 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：15
页码：5417-5420
DOI：10.1073/pnas.0307136101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：It is found that the addition of hexamethylphosphoramide to the solution of an alkyne, Et2Zn, and (S)-1,1'-bi-2-naphthol in methylene chloride allows the generation of an alkynylzinc at room temperature and shows highly enantioselective additions to aldehydes. The mild condition for the formation of the alkynylzinc reagent enables the use of functional alkynes in this asymmetric reaction with excellent enantioselectivity. It avoids the reflux of the toluene solutions of the alkynes and Et2Zn as previously reported.
关键词：asymmetric catalysis ; alkynylzinc additions ; propargylic alcohols