文章基本信息

标题：Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ32 HIV-resistance allele
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作者：Alison P. Galvani ; Montgomery Slatkin
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：25
页码：15276-15279
DOI：10.1073/pnas.2435085100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The high frequency, recent origin, and geographic distribution of the CCR5-{Delta}32 deletion allele together indicate that it has been intensely selected in Europe. Although the allele confers resistance against HIV-1, HIV has not existed in the human population long enough to account for this selective pressure. The prevailing hypothesis is that the selective rise of CCR5-{Delta}32 to its current frequency can be attributed to bubonic plague. By using a population genetic framework that takes into account the temporal pattern and age-dependent nature of specific diseases, we find that smallpox is more consistent with this historical role.
关键词：selection ; epidemic ; disease resistance ; population genetics