文章基本信息

标题：Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments?
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作者：Changbong Hyeon ; D. Thirumalai
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：18
页码：10249-10253
DOI：10.1073/pnas.1833310100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：By considering temperature effects on the mechanical unfolding rates of proteins and RNA, whose energy landscape is rugged, the question posed in the title is answered in the affirmative. Adopting a theory by Zwanzig [Zwanzig, R. (1988) Proc. Natl. Acad. Sci. USA 85, 2029-2030], we show that, because of roughness characterized by an energy scale {varepsilon