文章基本信息

标题：A ligand-binding pocket in the dengue virus envelope glycoprotein
本地全文：下载
作者：Yorgo Modis ; Steven Ogata ; David Clements 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：12
页码：6986-6991
DOI：10.1073/pnas.0832193100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a {beta}-hairpin at the interface between two domains. These features point to a structural pathway for the fusion-activating transition and suggest a strategy for finding small-molecule inhibitors of dengue and other flaviviruses.