文章基本信息

标题：Differential activation of the human orbital, mid-ventrolateral, and mid-dorsolateral prefrontal cortex during the processing of visual stimuli
本地全文：下载
作者：Michael Petrides ; Bessie Alivisatos ; Stephen Frey 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：8
页码：5649-5654
DOI：10.1073/pnas.072092299
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：There is considerable uncertainty about the precise functional contribution of the different parts of the prefrontal cortex to mnemonic processing. Changes in regional cerebral blood flow were measured with positron emission tomography in normal human subjects exposed to abstract visual designs under various conditions. It was demonstrated that the processing of stimuli that deviate from expectations involves selectively the orbitofrontal cortex, namely the part of the frontal cortex that is preferentially linked with the limbic system. By contrast, when the subject is making an explicit decision on the contents of memory (e.g., judgments of relative stimulus familiarity), the mid-ventrolateral prefrontal cortex is involved. The mid-dorsolateral prefrontal cortex is engaged when monitoring of information within working memory is required.