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  • 标题:The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure
  • 本地全文:下载
  • 作者:Jonathan D. Dinman ; Sara Richter ; Ewan P. Plant
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2002
  • 卷号:99
  • 期号:8
  • 页码:5331-5336
  • DOI:10.1073/pnas.082102199
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The cis-acting mRNA elements that promote programmed -1 ribosomal frameshifting present a natural target for the rational design of antiretroviral chemotherapies. It has been commonly accepted that the HIV-1 frameshifting signal is special, because its downstream enhancer element consists of a simple mRNA stem loop rather than a more complex secondary structure such as a pseudoknot. Here we present three lines of evidence, bioinformatic, structural, and genetic, showing that the biologically relevant HIV-1 frameshift signal contains a complex RNA structure that likely includes an extended RNA triple-helix region. We suggest that the potential intramolecular triplex structure is essential for viral propagation and viability, and that small molecules targeted to this RNA structure may possess antiretroviral activities.
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