文章基本信息

标题：Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus
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作者：Bernice Porjesz ; Laura Almasy ; Howard J. Edenberg 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：6
页码：3729-3733
DOI：10.1073/pnas.052716399
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by {gamma}-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.