文章基本信息

标题：Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
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作者：Donald Metcalf ; Sandra Mifsud ; Ladina Di Rago 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：2
页码：943-948
DOI：10.1073/pnas.022628499
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Mice with inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) die in neonatal life with an IFN-{gamma}-dependent inflammatory disease dominated by fatty degeneration and necrosis of the liver. To establish the long-term pathological consequences of loss of SOCS-1 in mice, where initial survival was made possible by also deleting the IFN-{gamma} gene, a comparison was made of the lifespan of groups of SOCS-1-/- IFN-{gamma}-/-, SOCS-1+/+ IFN-{gamma}-/- and SOCS-1+/+ IFN-{gamma}+/+ mice. Mice lacking the genes for both SOCS-1 and IFN-{gamma} exhibited an accelerated death rate compared with control groups. Disease states developing selectively in SOCS-1-/- IFN-{gamma}-/- mice were polycystic kidneys, pneumonia, chronic skin ulcers, and chronic granulomas in the gut and various other organs. Mice of all three groups developed cataracts, but disease development was accelerated in the groups lacking IFN-{gamma}. SOCS-1-/- IFN-{gamma}-/- mice exhibited a slightly increased predisposition to the development of T lymphoid leukemia, either spontaneous or radiation-induced. The development of polycystic kidneys may be caused by a developmental defect in renal-tubule organization noted in neonatal SOCS-1-/- mice. The chronic infections and granulomas of SOCS-1-/- IFN-{gamma}-/- mice may be based on autoaggression of SOCS-1-/- T lymphoid and related cells or a functional deficiency of these cells when lacking SOCS-1.