文章基本信息

标题：Protein–DNA computation by stochastic assembly cascade
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作者：Roy Bar-Ziv ; Tsvi Tlusty ; Albert Libchaber 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：18
页码：11589-11592
DOI：10.1073/pnas.162369099
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The assembly of RecA on single-stranded DNA is measured and interpreted as a stochastic finite-state machine that is able to discriminate fine differences between sequences, a basic computational operation. RecA filaments efficiently scan DNA sequence through a cascade of random nucleation and disassembly events that is mechanistically similar to the dynamic instability of microtubules. This iterative cascade is a multistage kinetic proofreading process that amplifies minute differences, even a single base change. Our measurements suggest that this stochastic Turing-like machine can compute certain integral transforms.