文章基本信息

标题：Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties
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作者：Gilles Crambert ; Maria Füzesi ; Haim Garty 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：17
页码：11476-11481
DOI：10.1073/pnas.182267299
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A family of small, single-span membrane proteins (the FXYD family) has recently been defined based on their sequence and structural homology. Some members of this family have already been identified as tissue-specific regulators of Na,K-ATPase (NKA). In the present study, we demonstrate that phospholemman (PLM) (FXYD1), so far considered to be a heart- and muscle-specific channel or channel-regulating protein, associates specifically and stably with six different -{beta} isozymes of NKA after coexpression in Xenopus oocytes, and with 1-{beta