文章基本信息

标题：Inosine induces axonal rewiring and improves behavioral outcome after stroke
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作者：Peng Chen ; David E. Goldberg ; Bryan Kolb 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：13
页码：9031-9036
DOI：10.1073/pnas.132076299
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cerebral infarct (stroke) often causes devastating and irreversible losses of function, in part because of the brain's limited capacity for anatomical reorganization. The purine nucleoside inosine has previously been shown to induce neurons to express a set of growth-associated proteins and to extend axons in culture and in vivo. We show here that in adult rats with unilateral cortical infarcts, inosine stimulated neurons on the undamaged side of the brain to extend new projections to denervated areas of the midbrain and spinal cord. This growth was paralleled by improved performance on several behavioral measures.