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标题：Inositol hexakisphosphate promotes dynamin I- mediated endocytosis
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作者：Marianne Høy ; Alexander M. Efanov ; Alejandro M. Bertorello 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：10
页码：6773-6777
DOI：10.1073/pnas.102157499
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Membrane homeostasis is maintained by exocytosis and endocytosis. The molecular mechanisms regulating the interplay between these two processes are not clear. Inositol hexakisphosphate (InsP6) is under metabolic control and serves as a signal in the pancreatic {beta} cell stimulus-secretion coupling by increasing Ca2+-channel activity and insulin exocytosis. We now show that InsP6 also promotes dynamin I-mediated endocytosis in the pancreatic {beta} cell. This effect of InsP6 depends on calcineurin-induced dephosphorylation and is accounted for by both activation of protein kinase C and inhibition of the phosphoinositide phosphatase synaptojanin and thereby formation of phosphatidylinositol 4,5-bisphosphate. In regulating both exocytosis and endocytosis, InsP6 thus may have an essential integral role in membrane trafficking.