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  • 标题:Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels
  • 本地全文:下载
  • 作者:Francisco J. Urbano ; Erika S. Piedras-Rentería ; Kisun Jun
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2003
  • 卷号:100
  • 期号:6
  • 页码:3491-3496
  • DOI:10.1073/pnas.0437991100
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Transmission at the mouse neuromuscular junction normally relies on P/Q-type channels, but became jointly dependent on both N- and R-type Ca2+ channels when the P/Q-type channel 1A subunit was deleted. R-type channels lay close to Ca2+ sensors for exocytosis and IK(Ca) channel activation, like the P/Q-type channels they replaced. In contrast, N-type channels were less well localized, but abundant enough to influence secretion strongly, particularly when action potentials were prolonged. Our data suggested that active zone structures may select among multiple Ca2+ channels in the hierarchy P/Q>R>N. The 1A-/- neuromuscular junction displayed several other differences from wild-type: lowered quantal content but greater ability to withstand reductions in the Ca2+/Mg2+ ratio, and little or no paired-pulse facilitation, the latter findings possibly reflecting compensatory mechanisms at individual release sites. Changes in presynaptic function were also associated with a significant reduction in the size of postsynaptic acetylcholine receptor clusters.
  • 关键词:neuromuscular junction‖α1A knockout‖paired-pulse facilitation‖ SNX-482‖Ca2+-activated potassium channel
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