文章基本信息

标题：A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis
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作者：Daniel M. Keenan ; Julio Licinio ; Johannes D. Veldhuis 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2001
卷号：98
期号：7
页码：4028-4033
DOI：10.1073/pnas.051624198
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The present work develops and implements a biomathematical statement of how reciprocal connectivity drives stress-adaptive homeostasis in the corticotropic (hypothalamo-pituitary-adrenal) axis. In initial analyses with this interactive construct, we test six specific a priori hypotheses of mechanisms linking circadian (24-h) rhythmicity to pulsatile secretory output. This formulation offers a dynamic framework for later statistical estimation of unobserved in vivo neurohormone secretion and within-axis, dose-responsive interfaces in health and disease. Explication of the core dynamics of the stress-responsive corticotropic axis based on secure physiological precepts should help to unveil new biomedical hypotheses of stressor-specific system failure.