文章基本信息

标题：Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
本地全文：下载
作者：Ronald B. DeMattos ; Kelly R. Bales ; David J. Cummins 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2001
卷号：98
期号：15
页码：8850-8855
DOI：10.1073/pnas.151261398
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Active immunization with the amyloid {beta} (A{beta}) peptide has been shown to decrease brain A{beta} deposition in transgenic mouse models of Alzheimer's disease and certain peripherally administered anti-A{beta} antibodies were shown to mimic this effect. In exploring factors that alter A{beta} metabolism and clearance, we found that a monoclonal antibody (m266) directed against the central domain of A{beta} was able to bind and completely sequester plasma A{beta}. Peripheral administration of m266 to PDAPP transgenic mice, in which A{beta} is generated specifically within the central nervous system (CNS), results in a rapid 1,000-fold increase in plasma A{beta