文章基本信息

标题：Homologous DNA recombination in vertebrate cells
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作者：Eiichiro Sonoda ; Minoru Takata ; Yukiko M. Yamashita 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2001
卷号：98
期号：15
页码：8388-8394
DOI：10.1073/pnas.111006398
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cells deficient in genes of the RAD52 epistasis group reveal that the role of each protein is not necessarily the same as that of the corresponding yeast gene product. This review addresses the roles and mechanisms of homologous recombination-mediated repair with a special emphasis on differences between yeast and vertebrate cells.
关键词：DT40 ; reverse genetic study ; double-strand break repair ; Rad 51 family