文章基本信息

标题：Requirement of the nicotinic acetylcholine receptor β2 subunit for the anatomical and functional development of the visual system
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作者：Francesco Mattia Rossi ; Tommaso Pizzorusso ; Vittorio Porciatti 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2001
卷号：98
期号：11
页码：6453-6458
DOI：10.1073/pnas.101120998
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：In the mammalian visual system the formation of eye-specific layers at the thalamic level depends on retinal waves of spontaneous activity, which rely on nicotinic acetylcholine receptor activation. We found that in mutant mice lacking the {beta}2 subunit of the neuronal nicotinic receptor, but not in mice lacking the 4 subunit, retinofugal projections do not segregate into eye-specific areas, both in the dorso-lateral geniculate nucleus and in the superior colliculus. Moreover, {beta}2-/- mice show an expansion of the binocular subfield of the primary visual cortex and a decrease in visual acuity at the cortical level but not in the retina. We conclude that the {beta}2 subunit of the nicotinic acetylcholine receptor is necessary for the anatomical and functional development of the visual system.