文章基本信息

标题：Regulation of T cell activation, anxiety, and male aggression by RGS2
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作者：Antonio J. Oliveira-dos-Santos ; Goichi Matsumoto ; Bryan E. Snow 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2000
卷号：97
期号：22
页码：12272-12277
DOI：10.1073/pnas.220414397
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Regulators of G protein signaling (RGS) proteins accelerate the GTPase activity of G protein subunits in vitro, negatively regulating G protein-coupled receptor signaling. The physiological role of mammalian RGS proteins is largely unknown. The RGS family member rgs2 was cloned as an immediate early response gene up-regulated in T lymphocytes after activation. To investigate the role of RGS2 in vivo, we generated rgs2-deficient mice. We show that targeted mutation of rgs2 in mice leads to reduced T cell proliferation and IL-2 production, which translates in an impaired antiviral immunity in vivo. Interestingly, rgs2-/- mice also display increased anxiety responses and decreased male aggression in the absence of cognitive or motor deficits. RGS2 also controls synaptic development and basal electrical activity in hippocampal CA1 neurons. Thus, RGS2 plays an important role in T cell activation, synapse development in the hippocampus, and emotive behaviors.