文章基本信息

标题：Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA
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作者：R O Dempcy ; J Luo ; T C Bruice 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1996
卷号：93
期号：9
页码：4326-4330
DOI：10.1073/pnas.93.9.4326
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].