文章基本信息

标题：Circadian expression of the luciferin-binding protein correlates with the binding of a protein to the 3' untranslated region of its mRNA
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作者：M Mittag ; D H Lee ; J W Hastings 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1994
卷号：91
期号：12
页码：5257-5261
DOI：10.1073/pnas.91.12.5257
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The circadian-expressed luciferin-binding protein from the dinoflagellate Gonyaulax polyedra is regulated at the translational level. We detected a protein, apparently a dimer, that binds specifically to the 3' untranslated region of its mRNA. Its binding site was localized within a 22-nt region in the 3' untranslated region containing seven UG repeats. The binding activity of this protein cycles on a daily basis, decreasing at the beginning of the night when synthesis of luciferin-binding protein starts and increasing at the end of the night when synthesis of luciferin-binding protein stops. This suggests that it functions as a clock-controlled repressor, preventing the translation of lbp mRNA during the day.