文章基本信息

标题：Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae
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作者：M A White ; M Dominska ; T D Petes 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1993
卷号：90
期号：14
页码：6621-6625
DOI：10.1073/pnas.90.14.6621
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The full activity of a recombination initiation site located 5' of HIS4 requires the binding of the transcription factors RAP1, BAS1, and BAS2. Two RAP1 binding sites can substitute for the wild-type initiation site. A 51-bp region of telomeric DNA inserted upstream of either HIS4 or ARG4 very strongly stimulates recombination. We suggest that the ability of transcription factors to induce recombination is a consequence of an altered chromatin structure that favors the entry of proteins that initiate recombination, rather than an effect of these factors on transcription.