文章基本信息

标题：Extracellular leucine-rich repeats as a platform for receptor/coreceptor complex formation
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作者：Yvon Jaillais ; Youssef Belkhadir ; Emilia Balsemão-Pires 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2011
卷号：108
期号：20
页码：8503-8507
DOI：10.1073/pnas.1103556108
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Receptor kinases with leucine-rich repeat (LRR) extracellular domains form the largest family of receptors in plants. In the few cases for which there is mechanistic information, ligand binding in the extracellular domain often triggers the recruitment of a LRR-coreceptor kinase. The current model proposes that this recruitment is mediated by their respective kinase domains. Here, we show that the extracellular LRR domain of BRI1-ASSOCIATED KINASE1 (BAK1), a coreceptor involved in the disparate processes of cell surface steroid signaling and immunity in plants, is critical for its association with specific ligand-binding LRR-containing receptors. The LRRs of BAK1 thus serve as a platform for the molecular assembly of signal-competent receptors. We propose that this mechanism represents a paradigm for LRR receptor activation in plants.
关键词：brassinosteroid signaling ; flagellin signaling ; plant innate immunity ; Receptor-like kinase ; signaling crosstalk