文章基本信息

标题：Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity
本地全文：下载
作者：Patrick J. Drew ; Andy Y. Shih ; David Kleinfeld 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2011
卷号：108
期号：20
页码：8473-8478
DOI：10.1073/pnas.1100428108
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Neural activity in the brain is followed by localized changes in blood flow and volume. We address the relative change in volume for arteriole vs. venous blood within primary vibrissa cortex of awake, head-fixed mice. Two-photon laser-scanning microscopy was used to measure spontaneous and sensory evoked changes in flow and volume at the level of single vessels. We find that arterioles exhibit slow (<1 Hz) spontaneous increases in their diameter, as well as pronounced dilation in response to both punctate and prolonged stimulation of the contralateral vibrissae. In contrast, venules dilate only in response to prolonged stimulation. We conclude that stimulation that occurs on the time scale of natural stimuli leads to a net increase in the reservoir of arteriole blood. Thus, a "bagpipe" model that highlights arteriole dilation should augment the current "balloon" model of venous distension in the interpretation of fMRI images.
关键词：blood oxygen level-dependent functional MRI ; neurovascular coupling ; two-photon imaging ; vasomotion ; vibrissa somatosensation