文章基本信息

标题：Alzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerization
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作者：Hyung Jin Ahn ; Daria Zamolodchikov ; Marta Cortes-Canteli 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：50
页码：21812-21817
DOI：10.1073/pnas.1010373107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Increasing evidence supports a vascular contribution to Alzheimer's disease (AD), but a direct connection between AD and the circulatory system has not been established. Previous work has shown that blood clots formed in the presence of the {beta}-amyloid peptide (A{beta}), which has been implicated in AD, have an abnormal structure and are resistant to degradation in vitro and in vivo. In the present study, we show that A{beta} specifically interacts with fibrinogen with a Kd of 26.3 {+/-} 6.7 nM, that the binding site is located near the C terminus of the fibrinogen {beta}-chain, and that the binding causes fibrinogen to oligomerize. These results suggest that the interaction between A{beta} and fibrinogen modifies fibrinogen's structure, which may then lead to abnormal fibrin clot formation. Overall, our study indicates that the interaction between A{beta} and fibrinogen may be an important contributor to the vascular abnormalities found in AD.