文章基本信息

标题：Sympathetic nervous system control of anti-influenza CD8+ T cell responses
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作者：Kristie M. Grebe ; Heather D. Hickman ; Kari R. Irvine 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：13
页码：5300-5305
DOI：10.1073/pnas.0808851106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic. Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8+ T cell responses to viral and cellular antigens presented by direct priming or cross-priming. The sympathetic nervous system also suppresses antiviral CD4+ T cell responses, but this is not required for suppressing CD8+ T cell responses. Adoptive transfer experiments indicate that enhanced CD8+ responses do not result from permanent alterations in CD8+ T cell function in sympathectomized mice. Rather, additional findings suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to activate naive CD8+ T cells. We also show that antiviral CD8+ T cell responses are enhanced by administration of a {beta}2 (but not {beta}1 or {alpha}) adrenergic antagonist. These findings demonstrate a critical role for the sympathetic nervous system in limiting CD8+ T cell responses and indicate that CD8+ T cell responses may be altered in patients using {beta}-blockers, one of the most widely prescribed classes of drugs.
关键词：antigen presentation ; vaccine ; cross-priming ; direct-priming ; dendritic cell