文章基本信息

标题：Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
本地全文：下载
作者：Dean R. Artis ; Jack J. Lin ; Chao Zhang 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：1
页码：262-267
DOI：10.1073/pnas.0811325106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：In a search for more effective anti-diabetic treatment, we used a process coupling low-affinity biochemical screening with high-throughput co-crystallography in the design of a series of compounds that selectively modulate the activities of all three peroxisome proliferator-activated receptors (PPARs), PPAR{alpha
关键词：adiponectin ; diabetes ; partial agonist ; PPAR pan-agonist ; Scaffold-based drug discovery