文章基本信息

标题：Night eating and obesity in the EP3R-deficient mouse
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作者：Manuel Sanchez-Alavez ; Izabella Klein ; Sara E. Brownell 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2007
卷号：104
期号：8
页码：3009-3014
DOI：10.1073/pnas.0611209104
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Adult mice carrying a null mutation of the prostanoid receptor EP3R (EP3R-/- mice) exhibit increased frequency of feeding during the light cycle of the day and develop an obese phenotype under a normal fat diet fed ad libitum. EP3R-/- mice show increased motor activity, which is not sufficient to offset the increased feeding leading to increased body weight. Altered "nocturnal" activity and feeding behavior is present from a very early age and does not seem to require age-dependent factors for the development of obesity. Obesity in EP3R-/- mice is characterized by elevated leptin and insulin levels and >20% higher body weight compared with WT littermates. Abdominal and subcutaneous fat and increased liver weight account for the weight increase in EP3R-/- mice. These observations expand the roles of prostaglandin E2 signaling in metabolic regulation beyond the reported stimulation of leptin release from adipose tissue to involve actions mediated by EP3R in the regulation of sleep architecture and feeding behavior. The findings add to the growing literature on links between inflammatory signaling and obesity.
关键词：body weight ; insulin ; leptin ; prostanoid receptor ; signaling