文章基本信息

标题：Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
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作者：Susanne Tranguch ; Joyce Cheung-Flynn ; Takiko Daikoku 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2005
卷号：102
期号：40
页码：14326-14331
DOI：10.1073/pnas.0505775102
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Embryo implantation in the uterus is a critical step in mammalian reproduction, requiring preparation of the uterus receptive to blastocyst implantation. Uterine receptivity, also known as the window of implantation, lasts for a limited period, and it is during this period blastocysts normally implant. Ovarian steroid hormones estrogen and progesterone (P4) are the primary regulators of this process. The immunophilin FKBP52 serves as a cochaperone for steroid hormone nuclear receptors to govern appropriate hormone action in target tissues. Here we show a critical role for FKBP52 in mouse implantation. This immunophilin has unique spatiotemporal expression in the uterus during implantation, and females missing the Fkbp52 gene have complete implantation failure due to lack of attainment of uterine receptivity. The overlapping uterine expression of FKBP52 with nuclear progesterone receptor (PR) in wild-type mice together with reduced P4 binding to PR, attenuated PR transcriptional activity and down-regulation of several P4-regulated genes in uteri of Fkbp52-/- mice, establishes this cochaperone as a critical regulator of uterine P4 function. Interestingly, ovulation, another P4-mediated event, remains normal. Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation.
关键词：mouse ; uterus ; ovulation ; blastocyst ; progesterone receptor