文章基本信息

标题：DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor
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作者：He Zhou ; Yunping Luo ; Jeng-fan Lo 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2005
卷号：102
期号：31
页码：10846-10851
DOI：10.1073/pnas.0502208102
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The interaction of NKG2D, a stimulatory receptor expressed on natural killer (NK) cells and activated CD8+ T cells, and its ligands mediates stimulatory and costimulatory signals to these cells. Here, we demonstrate that DNA-based vaccines, encoding syngeneic or allogeneic NKG2D ligands together with tumor antigens such as survivin or carcinoembryonic antigen, markedly activate both innate and adaptive antitumor immunity. Such vaccines result in highly effective, NK- and CD8+ T cell-mediated protection against either breast or colon carcinoma cells in prophylactic and therapeutic settings. Notably, this protection was irrespective of the NKG2D ligand expression level of the tumor cells. Hence, this strategy has the potential to lead to widely applicable and possibly clinically useful DNA-based cancer vaccines.
关键词：NK cells ; NKG2D ligands ; T cells ; survivin ; Peyer's patches