文章基本信息

标题：Nicotine activates immature “silent” connections in the developing hippocampus
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作者：Laura Maggi ; Corentin Le Magueresse ; Jean-Pierre Changeux 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：4
页码：2059-2064
DOI：10.1073/pnas.0437947100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：In the hippocampus at birth, most glutamatergic synapses are immature and functionally "silent" either because the neurotransmitter is released in insufficient amount to activate low-affinity -amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors or because the appropriate receptor system is missing or nonfunctional. Here we show that, in the newborn rat, a brief application of nicotine at immature Schaffer collateral-CA1 connections strongly enhances neurotransmitter release and converts presynaptically silent synapses into conductive ones. This effect is persistent and can be mimicked by endogenous acetylcholine released from cholinergic fibers. Thus, during a critical period of postnatal development, activation of nicotinic acetylcholine receptors contributes to the maturation of functional synaptic contacts and the wiring of adult hippocampal circuitry.
关键词：excitatory postsynaptic currents‖cholinergic stimulation‖Schaffer collateral-CA1 synapses‖presynaptic effect‖increased probability of glutamate release