文章基本信息

标题：Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
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作者：Devin V. McAllister ; Ping M. Wang ; Shawn P. Davis 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：24
页码：13755-13760
DOI：10.1073/pnas.2331316100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Arrays of micrometer-scale needles could be used to deliver drugs, proteins, and particles across skin in a minimally invasive manner. We therefore developed microfabrication techniques for silicon, metal, and biodegradable polymer microneedle arrays having solid and hollow bores with tapered and beveled tips and feature sizes from 1 to 1,000 {micro}m. When solid microneedles were used, skin permeability was increased in vitro by orders of magnitude for macromolecules and particles up to 50 nm in radius. Intracellular delivery of molecules into viable cells was also achieved with high efficiency. Hollow microneedles permitted flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats.
关键词：transdermal drug delivery ; skin ; microelectromechanical systems ; solid microneedle ; hollow needle injection