文章基本信息

标题：An emotion-induced retrograde amnesia in humans is amygdala- and β-adrenergic-dependent
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作者：B. A. Strange ; R. Hurlemann ; R. J. Dolan 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：23
页码：13626-13631
DOI：10.1073/pnas.1635116100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The influence of emotion on human memory is associated with two contradictory effects in the form of either emotion-induced enhancements or decrements in memory. In a series of experiments involving single word presentation, we show that enhanced memory for emotional words is strongly coupled to decrements in memory for items preceding the emotional stimulus, an effect that is more pronounced in women. These memory effects would appear to depend on a common neurobiological substrate, in that enhancements and decrements are reversed by propranolol, a {beta}-adrenergic antagonist, and abolished by selective bilateral amygdala damage. Thus, our findings suggest that amygdala-dependent {beta}-adrenergic modulation of episodic encoding has costs as well as benefits.