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  • 标题:Promoting social behavior with oxytocin in high-functioning autism spectrum disorders
  • 本地全文:下载
  • 作者:Elissar Andari ; Jean-René Duhamel ; Tiziana Zalla
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2010
  • 卷号:107
  • 期号:9
  • 页码:4389-4394
  • DOI:10.1073/pnas.0910249107
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Social adaptation requires specific cognitive and emotional competences. Individuals with high-functioning autism or with Asperger syndrome cannot understand or engage in social situations despite preserved intellectual abilities. Recently, it has been suggested that oxytocin, a hormone known to promote mother-infant bonds, may be implicated in the social deficit of autism. We investigated the behavioral effects of oxytocin in 13 subjects with autism. In a simulated ball game where participants interacted with fictitious partners, we found that after oxytocin inhalation, patients exhibited stronger interactions with the most socially cooperative partner and reported enhanced feelings of trust and preference. Also, during free viewing of pictures of faces, oxytocin selectively increased patients' gazing time on the socially informative region of the face, namely the eyes. Thus, under oxytocin, patients respond more strongly to others and exhibit more appropriate social behavior and affect, suggesting a therapeutic potential of oxytocin through its action on a core dimension of autism.
  • 关键词:cognition ; neurodevelopmental disorder ; recovery ; Syntocinon
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