文章基本信息

标题：Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis
本地全文：下载
作者：Paul M. Kim ; Xin Duan ; Alex S. Huang 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：7
页码：3175-3179
DOI：10.1073/pnas.0914706107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：D-Aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development and survival of newborn neurons and survival. Because D-aspartate is a potential endogenous ligand for NMDA receptors, the loss of which elicits a phenotype resembling DR depletion, D-aspartate may function as a modulator of adult neurogenesis.
关键词：neuronal development ; neural progenitor cells ; hippocampus ; NMDA receptor ; neuroendocrine