文章基本信息

标题：Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein
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作者：Benjamin G. Hale ; Philip S. Kerry ; David Jackson 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：5
页码：1954-1959
DOI：10.1073/pnas.0910715107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Seasonal epidemics and periodic worldwide pandemics caused by influenza A viruses are of continuous concern. The viral nonstructural (NS1) protein is a multifunctional virulence factor that antagonizes several host innate immune defenses during infection. NS1 also directly stimulates class IA phosphoinositide 3-kinase (PI3K) signaling, an essential cell survival pathway commonly mutated in human cancers. Here, we present a 2.3-A resolution crystal structure of the NS1 effector domain in complex with the inter-SH2 (coiled-coil) domain of p85{beta
关键词：activation loop ; coiled-coil ; crystallography ; PI3-kinase