文章基本信息

标题：Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene
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作者：Magda Forsberg ; Marie Carlén ; Konstantinos Meletis 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：33
页码：14657-14661
DOI：10.1073/pnas.1009412107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a differentiated fate of an unrelated somatic lineage, by ectopic expression of the Ets transcription factor PU.1. The reprogrammed cells display a marker profile and functional characteristics of monocytes and integrate into tissues after transplantation. The failure to reprogram lineage-committed neural cells to monocytes with PU.1 suggests that neural stem cells are uniquely amenable to reprogramming.
关键词：PU.1 ; Ets transcription factor ; transdifferentiation ; microglia