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  • 标题:MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro
  • 本地全文:下载
  • 作者:Yun Fang ; Congzhu Shi ; Elisabetta Manduchi
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2010
  • 卷号:107
  • 期号:30
  • 页码:13450-13455
  • DOI:10.1073/pnas.1002120107
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:A chronic proinflammatory state precedes pathological change in arterial endothelial cells located within regions of susceptibility to atherosclerosis. The potential contributions of regulatory microRNAs to this disequilibrium were investigated by artery site-specific profiling in normal adult swine. Expression of endothelial microRNA10a (miR-10a) was lower in the athero-susceptible regions of the inner aortic arch and aorto-renal branches than elsewhere. Expression of Homeobox A1 (HOXA1), a known miR-10a target, was up-regulated in the same locations. Endothelial transcriptome microarray analysis of miR-10a knockdown in cultured human aortic endothelial cells (HAEC) identified I{kappa}B/NF-{kappa}B-mediated inflammation as the top category of up-regulated biological processes. Phosphorylation of I{kappa}B{alpha
  • 关键词:β-transducing repeat-containing gene ; hemodynamics ; mitogen-activated kinase kinase kinase 7 ; NF-κB
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