文章基本信息

标题：Membrane potential is important for bacterial cell division
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作者：Henrik Strahl ; Leendert W. Hamoen
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：27
页码：12281-12286
DOI：10.1073/pnas.1005485107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Many cell division-related proteins are located at specific positions in the bacterial cell, and this organized distribution of proteins requires energy. Here, we report that the proton motive force, or more specifically the (trans)membrane potential, is directly involved in protein localization. It emerged that the membrane potential modulates the distribution of several conserved cell division proteins such as MinD, FtsA, and the bacterial cytoskeletal protein MreB. We show for MinD that this is based on the membrane potential stimulated binding of its C-terminal amphipathic helix. This function of the membrane potential has implications for how these morphogenetic proteins work and provide an explanation for the effects observed with certain antimicrobial compounds.
关键词：cytoskeleton ; MreB ; MinD ; FtsA ; antibiotics