文章基本信息

标题：Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
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作者：Carsten Krieg ; Sven Létourneau ; Giuseppe Pantaleo 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：26
页码：11906-11911
DOI：10.1073/pnas.1002569107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：IL-2 immunotherapy is an attractive treatment option for certain metastatic cancers. However, administration of IL-2 to patients can lead, by ill-defined mechanisms, to toxic adverse effects including severe pulmonary edema. Here, we show that IL-2-induced pulmonary edema is caused by direct interaction of IL-2 with functional IL-2 receptors (IL-2R) on lung endothelial cells in vivo. Treatment of mice with high-dose IL-2 led to efficient expansion of effector immune cells expressing high levels of IL-2R{beta}{gamma
关键词：cytokine ; cytokine/mAb complexes ; NK cell ; T cell ; tumor