文章基本信息

标题：Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection
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作者：Wenli Liu ; Ming Yan ; Yueqin Liu 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：24
页码：11056-11061
DOI：10.1073/pnas.1001269107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Olfactomedin 4 (OLFM4) is a glycoprotein that has been found to be up-regulated in inflammatory bowel diseases and Helicobacter pylori infected patients. However, its role in biological processes such as inflammation or other immune response is not known. In this study, we generated OLFM4 KO mice to investigate potential role(s) of OLFM4 in gastric mucosal responses to H. pylori infection. H. pylori colonization in the gastric mucosa of OLFM4 KO mice was significantly lower compared with WT littermates. The reduced bacterial load was associated with enhanced infiltration of inflammatory cells in gastric mucosa. Production and expression of proinflammatory cytokines/chemokines such as IL-1{beta
关键词：NF-κB ; nucleotide oligomerization domain-1 and -2