文章基本信息

标题：Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance
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作者：Daniel A. Kahn ; David Baltimore
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：20
页码：9299-9304
DOI：10.1073/pnas.1003909107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A fetus is inherently antigenic to its mother and yet is not rejected. The T regulatory (Treg) subset of CD4+ T cells can limit immune responses and has been implicated in maternal tolerance of the fetus. Using virgin inbred mice undergoing a first syngenic pregnancy, in which only the male fetuses are antigenic, we demonstrate a maternal splenocyte proliferative response to the CD4+ T cell restricted epitope of the male antigen (H-Y) in proportion to the fetal antigen load. A portion of the maternal immune response to fetal antigens is Treg in nature. The bystander suppressive function of pregnancy-generated Tregs requires the presence of the fetal antigen, demonstrating their inherent antigen specificity. In vivo targeting of diphtheria toxin to kill Tregs leads to a lower fraction of live male offspring and a selective reduction in mass of the surviving males. Thus, Tregs generated in the context of pregnancy function in an antigen-specific manner to limit the maternal immune response to the fetus in a successful pregnancy.
关键词：denileukin diftitox ; Medawar ; H-Y