文章基本信息

标题：Systematic discovery of nonobvious human disease models through orthologous phenotypes
本地全文：下载
作者：Kriston L. McGary ; Tae Joo Park ; John O. Woods 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：14
页码：6544-6549
DOI：10.1073/pnas.0910200107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Biologists have long used model organisms to study human diseases, particularly when the model bears a close resemblance to the disease. We present a method that quantitatively and systematically identifies nonobvious equivalences between mutant phenotypes in different species, based on overlapping sets of orthologous genes from human, mouse, yeast, worm, and plant (212,542 gene-phenotype associations). These orthologous phenotypes, or phenologs, predict unique genes associated with diseases. Our method suggests a yeast model for angiogenesis defects, a worm model for breast cancer, mouse models of autism, and a plant model for the neural crest defects associated with Waardenburg syndrome, among others. Using these models, we show that SOX13 regulates angiogenesis, and that SEC23IP is a likely Waardenburg gene. Phenologs reveal functionally coherent, evolutionarily conserved gene networks--many predating the plant-animal divergence--capable of identifying candidate disease genes.
关键词：angiogenesis ; bioinformatics ; evolution ; gene-phenotype associations ; homology