文章基本信息

标题：Activation and synchronization of the oscillatory morphodynamics in multicellular monolayer
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作者：Shao-Zhen Lin ; Bo Li ; Ganhui Lan 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：31
页码：8157-8162
DOI：10.1073/pnas.1705492114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Oscillatory morphodynamics provides necessary mechanical cues for many multicellular processes. Owing to their collective nature, these processes require robustly coordinated dynamics of individual cells, which are often separated too distantly to communicate with each other through biomaterial transportation. Although it is known that the mechanical balance generally plays a significant role in the systems’ morphologies, it remains elusive whether and how the mechanical components may contribute to the systems’ collective morphodynamics. Here, we study the collective oscillations in the Drosophila amnioserosa tissue to elucidate the regulatory roles of the mechanical components. We identify that the tensile stress is the key activator that switches the collective oscillations on and off. This regulatory role is shown analytically using the Hopf bifurcation theory. We find that the physical properties of the tissue boundary are directly responsible for synchronizing the oscillatory intensity and polarity of all inner cells and for orchestrating the spatial oscillation patterns inthe tissue.
关键词：collective cell oscillations ; morphodynamics ; Hopf bifurcation